Biopharmaceuticals and Biotherapeutics: Recent Advancements
Over the past two decades there has been a decisive shift towards large molecule, biological drugs or biopharmaceuticals, and away from traditional chemically synthesised, small molecule drugs Revenue from biopharmaceuticals in 2016 was in the range of $280-300 billion and is forecasted to grow at about 10% for the foreseeable future. One particular biomolecule dominates though in biopharmaceuticals currently and that is the monoclonal antibody.
The number approved for use as biopharmaceuticals has steadily increased and in 2016 accounted for five of the top ten selling drugs globally with revenues of $46 billion
This appetite for monoclonal drugs shows no sign of abating with this article on the therapeutic monoclonal antibody market anticipating 2020 revenues of $125 billion. A recent FiercePharma report also predicted that by 2022 monoclonal antibodies will make up 60% of the top selling cancer drugs.
A biologic therapeutic product, also known as a biologic, is a therapeutic product developed to treat a variety of diseases. This biologic product can be a monoclonal antibody, a vaccine, a tissue, or various proteins such as cytokines, enzymes, fusion proteins, whole cells, and viral and nonviral gene therapies
- Cell-based therapeutics
- Biopharmaceutical and Drug Delivery
- Biotherapeutics
- Biomedical proteins
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