Vaccines Manufacturing: Challenges and Solutions

 

The biotechnology era has experienced significant changes in the number of companies involved in vaccine manufacturing as well as in the production systems they use. Nevertheless, challenges in this area are multiple. In the current vaccine-manufacturing environment, time to market and cost effectiveness are key issues that need to be addressed in addition to smooth R&D and clinical studies. Furthermore, scale up and safety are important for maintaining a successful manufacturing process. As a result, state-of-the-art technologies to simplify vaccine development and manufacturing are becoming ever-more crucial

Vaccine development was discussed as important for global security at the World Economic Forum in Davos, Switzerland in January 2015. The first draft of the US House of Representatives “21st Century Cures” initiative includes actions to speed up vaccine approval and coverage. Proposals seek to tighten timelines for the Centers for Disease Control and Prevention (CDC) to recommend new vaccines, for FDA to expedite vaccine exports, and for the National Institutes of Health (NIH) to advance vaccine development. Researchers are looking for formulations that reduce cold-chain requirements, methods to boost process yield, and new approaches to document product quality.

  • Gene-based vaccines
  • New technologies to vaccine discovery
  • Development and production of vaccines
  • Delivery systems

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